Hello and welcome to the forum!
Most folks will find the 6B to be too large for a desktop set up since they are 8.3" wide and 12.8" deep, but they will provide you with about 30 Hz more bass extension and fuller mids than the 5B, so if you have room for them I think the difference in sound quality would be apparent.
Hope that helps but please let me know if you have other questions!
Jason Hicks
Aperion Audio Guru